Comparative Prospective Study of the Management of Preventive Analgesia in Patients Undergoing Primary Total Knee Arthroplasty
Abstract
Background and Objective: Preventive analgesia is one that is administered hours or days before a total knee arthroplasty in order to reduce postoperative pain. The objective of this study was to compare and analyze the clinical efficiency of the use of preventive analgesia in patients undergoing total knee replacement. Methods: Sixty-six patients, divided into two groups of 33 patients, were evaluated prospectively and comparatively between November 2018 and March 2019. Group A received preoperative analgesia with a combination of etoricoxib, tramadol, and paracetamol, orally, 2 hours before surgery. Control group B did not receive anything. The postoperative pain of the patients was evaluated according to their own records on a visual analog scale at 12, 24, 48, 72 hours and one week after surgery. Results: A significant difference was observed at 24 hours between both groups, pain was significantly less for group A (p = 0.001), at 48 hours the difference was statistically lower than at 24 hours (p = 0.016). It was also observed that the control group required a greater number of rescues, although the difference was only significant at 24 hours (p = 0.047). Conclusion: The combination of etoricoxib, tramadol and paracetamol is effective, safe, costeffective and easy to administer, with a low rate of adverse effects; which represents an adequate scheme for the management of preventive analgesia.Level of Evidence: IIbDownloads
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