Aggressive Aneurysmal Bone Cyst of the Spine. Case report and Literature Review
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Published:
Dec 31, 2022
Keywords:
Aneurysmal bone cyst, thoracic spine, myelopathy
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Abstract
Introduction: An aneurysmal bone cyst is an expansive, lytic, pseudotumoral lesion that consists of blood-filled spaces separated by septa. It represents 15% of primary spinal tumors. An aggressive presentation is even rarer. Different therapeutic options are described depending on its stage and recurrence rate. We present the case of a patient with neurological involvement due to the aggressive behavior of an aneurysmal bone cyst in the thoracic spine, which required surgical treatment.
Conclusion: Treatment options for aneurysmal bone cysts must adapt to each case, depending on its characteristics.Level of Evidence: IV
Conclusion: Treatment options for aneurysmal bone cysts must adapt to each case, depending on its characteristics.Level of Evidence: IV
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Baigorria, J. F., Besse, M., Rosado Pardo, J. A., Steverlynck, A., & Sarotto, A. J. (2022). Aggressive Aneurysmal Bone Cyst of the Spine. Case report and Literature Review. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 87(6), 804-813. https://doi.org/10.15417/issn.1852-7434.2022.87.6.1470
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Case Presentations
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recurrence treated with multimodal intervention - A case report. Surg Neurol Int 2020;11:274.
https://doi.org/10.25259/SNI_466_2020
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19. Skubitz KM, Peltola JC, Santos ER, Cheng EY. Response of aneurysmal bone cyst to denosumab. Spine (Phila Pa 1976) 2015;40(22):E1201-4. https://doi.org/10.1097/BRS.0000000000001027
20. Kulkarni AG, Patel A. Denosumab: A potential new treatment option for recurrent aneurysmal bone cyst of the spine. SICOT J 2019;5:10. https://doi.org/10.1051/sicotj/2019007
21. Barbanti-Brodano G, Girolami M, Ghermandi R, Terzi S, Gasbarrini A, Bandiera S, et al. Aneurysmal bone
cyst of the spine treated by concentrated bone marrow: clinical cases and review of the literature. Eur Spine J
2017;26(Suppl 1):158-66. https://doi.org: 10.1007/s00586-017-4978-x
22. Chang CY, Kattapuram SV, Huang AJ, Simeone FJ, Torriani M, Bredella MA. Treatment of aneurysmal bone cysts by percutaneous CT-guided injection of calcitonin and steroid. Skeletal Radiol 2017;46(1):35-40.
https://doi.org/10.1007/s00256-016-2503-7
23. Sertbas I, Karatay M. Combined preoperative embolization and surgical treatment of a giant aneurysmal bone cyst in the lumbar spine: A case study. Turk Neurosurg 2020;30(3):462-4. https://doi.org/10.5137/1019-5149.JTN.24614-18.2
24. Amendola L, Simonetti L, Simoes CE, Bandiera S, De Iure F, Boriani S. Aneurysmal bone cyst of the mobile spine: the therapeutic role of embolization. Eur Spine J 2013;22(3):533-41. https://doi.org/10.1007/s00586-012-2566-7
appearance, and the pathogenesis. Arch Surg 1942;44:1004-25. Disponible en: https://jamanetwork.com/journals/jamasurgery/article-abstract/545805
2. Muratori F, Mondanelli N, Rizzo AR, Beltrami G, Giannotti S, Capanna R, et al. Aneurysmal bone cyst: A review of management. Surg Technol Int 2019;35:325-35. PMID: 31476792
3. Lam Y. Bone tumors: Benign bone tumors. FP Essent 2020;493:11-21. PMID: 32573182
4. Kiu A, Fung T, Chowdhary P, Jung S, Powell T, Boily M. Aneurysmal bone cyst in thoracolumbar spine. BJR Case
Rep 2020;6(3):20190133. https://doi.org/10.1259/bjrcr.20190133
5. Enneking WF. A staging system for musculoskeletal neoplasms. Clin Orthop Relat Res 1986;204:9-24.
PMID: 3456859
6. Abrar WA, Sarmast A, Sarabjit Singh AR, Khursheed N, Ali Z. Aneurysmal bone cysts of spine: an enigmatic entity. Neurol India 2020;68(4):843-9. https://doi.org/10.4103/0028-3886.293465
7. Desai SB, O’Brien C, Shaikh R, Hedequist D, Proctor M, Orbach DB, et al. Multidisciplinary management of spinal aneurysmal bone cysts: A single-center experience. Interv Neuroradiol 2019;25(5):564-9.
https://doi.org/10.1177%2F1591019919848130
8. Frassanito P, D’Onofrio GF, Pennisi G, Massimi L, Tamburrini G, Muto M, et al. Multimodal management
of aggressive recurrent aneurysmal bone cyst of spine: Case report and review of literature. World Neurosurg
2019;126:4237. https://doi.org/10.1016/j.wneu.2019.02.246
9. Medical Research Council. Aids to the examination of the peripheral nervous system, Memorandum no. 45.
London, UK: Her Majesty’s Stationery Office; 1981.
10. Jiménez-Ávila JM, Rodríguez-Pacheco AB, Bitar-Alatorre E, Ramírez-Consuegra A. Quiste óseo aneurismático de columna vertebral lumbar. Experiencia médico-quirúrgica. Reporte de un caso. Acta Ortop Mex 2011;25(2):130-4. Disponible en: https://www.medigraphic.com/pdfs/ortope/or-2011/or112k.pdf
11. Eun J, Oh Y. A case report of aneurysmal bone cyst of the thoracic spine treated by serial anterior and posterior fusion. Medicine (Baltimore) 2019;98(44):e17695. https://doi.org/10.1097/MD.0000000000017695
12. Jaiswal A, Vijay V, Kori P, Shukla R. Aneurysmal bone cyst of thoracic spine: case report and brief review of
literature. BMJ Case Reports 2013:bcr2013009265. https://doi.org/10.1136/bcr-2013-009265
13. Rodríguez-García R, Antonio-Hernández JA, Santiago-Ortiz R, Sosa-Guzmán JJ, Rodríguez-Cordova R. Quiste
óseo aneurismático gigante de columna vertebral. Rev Fac Med UNAM 2003;46(6):218-21. Disponible en:
https://www.medigraphic.com/pdfs/facmed/un-2003/un036c.pdf}
14. Zhao Q, Xu H, Min X, Yang L, Ren Y. Imaging features of vertebral aneurysmal bone cyst and the clinical value of interventional embolization. Exp Ther Med 2020;20(4):3832-6. https://doi.org/10.3892/etm.2020.9099
15. Wang T, Jia Q, Gao X, Fan R, Wu Z, Guo W, et al. Secondary aneurysmal bone cyst of the spine: Clinicopathological features, surgical modalities and outcomes. Clin Neurol Neurosurg 2020;188:105595.
https://doi.org/10.1016/j.clineuro.2019.105595
16. Kumar BY, Thirumal R, Chander SG. Aneurysmal bone cyst of thoracic spine with neurological deficit and its
recurrence treated with multimodal intervention - A case report. Surg Neurol Int 2020;11:274.
https://doi.org/10.25259/SNI_466_2020
17. Kamikonya N, Hishikawa Y, Kurisu K, Taniguchi M, Miura T. Aneurysmal bone cyst treated by high-energy, lowdose radiation therapy: a case report. Radiat Med 1991;9(2):54-6. PMID: 1947203.
18. Harrop JS, Schmidt MH, Boriani S, Shaffrey CI. Aggressive “benign” primary spine neoplasms: osteoblastoma,
aneurysmal bone cyst, and giant cell tumor. Spine (Phila Pa 1976) 2009;34(22 Suppl):S39-47. https://doi.org/10.1097/BRS.0b013e3181ba0024.
19. Skubitz KM, Peltola JC, Santos ER, Cheng EY. Response of aneurysmal bone cyst to denosumab. Spine (Phila Pa 1976) 2015;40(22):E1201-4. https://doi.org/10.1097/BRS.0000000000001027
20. Kulkarni AG, Patel A. Denosumab: A potential new treatment option for recurrent aneurysmal bone cyst of the spine. SICOT J 2019;5:10. https://doi.org/10.1051/sicotj/2019007
21. Barbanti-Brodano G, Girolami M, Ghermandi R, Terzi S, Gasbarrini A, Bandiera S, et al. Aneurysmal bone
cyst of the spine treated by concentrated bone marrow: clinical cases and review of the literature. Eur Spine J
2017;26(Suppl 1):158-66. https://doi.org: 10.1007/s00586-017-4978-x
22. Chang CY, Kattapuram SV, Huang AJ, Simeone FJ, Torriani M, Bredella MA. Treatment of aneurysmal bone cysts by percutaneous CT-guided injection of calcitonin and steroid. Skeletal Radiol 2017;46(1):35-40.
https://doi.org/10.1007/s00256-016-2503-7
23. Sertbas I, Karatay M. Combined preoperative embolization and surgical treatment of a giant aneurysmal bone cyst in the lumbar spine: A case study. Turk Neurosurg 2020;30(3):462-4. https://doi.org/10.5137/1019-5149.JTN.24614-18.2
24. Amendola L, Simonetti L, Simoes CE, Bandiera S, De Iure F, Boriani S. Aneurysmal bone cyst of the mobile spine: the therapeutic role of embolization. Eur Spine J 2013;22(3):533-41. https://doi.org/10.1007/s00586-012-2566-7