Limb and Trunk Lipoblastoma: Local Recurrence and Complications after Marginal Resection. A Multicenter Study
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Published:
Jun 25, 2022
Keywords:
Lipoblastoma, lipoblastomatosis, children, marginal resection
Main Article Content
Abstract
Objectives: Lipoblastoma is a rare benign neoplasm that resembles white fat and can occur as a localized (lipoblastoma) or diffuse (lipoblastomatosis) tumor. Due to its rarity, the literature is mostly limited to case reports. The purpose of this study was to determine the local recurrence rate and complications after marginal resection of lipoblastomas located in the extremities or the back.
Materials and Methods: We performed a multicenter retrospective review of the records of pediatric patients who had undergone surgical excision of lipoblastomas at 4 tertiary care institutions from 2008 to 2018. We recorded the demographic data, diagnostic method, the volume of the lesion, type of biopsy, complications, recurrence, and the need for additional procedures.
Results: Throughout the study, 17 patients met the inclusion criteria for evaluation. The average patient age was 3.9 years, and 65% were male. The most common locations included thighs (N 9), low back region (N 2), and buttocks (N 2). The mean preoperative mass volume was 305.5 cm3 (range: 10.2 cm3 - 1745.8 cm3). The mean duration of follow-up was 2.8 years (range: 8 months to 5.6 years). One patient experienced recurrence (5.9%). One patient had a retracted skin scarring in the gluteal area.
Conclusion: Marginal surgical resection of lipoblastomas located in the back or extremities showed a low recurrence rate at 2.8 years of follow-up and minimal complications.
Materials and Methods: We performed a multicenter retrospective review of the records of pediatric patients who had undergone surgical excision of lipoblastomas at 4 tertiary care institutions from 2008 to 2018. We recorded the demographic data, diagnostic method, the volume of the lesion, type of biopsy, complications, recurrence, and the need for additional procedures.
Results: Throughout the study, 17 patients met the inclusion criteria for evaluation. The average patient age was 3.9 years, and 65% were male. The most common locations included thighs (N 9), low back region (N 2), and buttocks (N 2). The mean preoperative mass volume was 305.5 cm3 (range: 10.2 cm3 - 1745.8 cm3). The mean duration of follow-up was 2.8 years (range: 8 months to 5.6 years). One patient experienced recurrence (5.9%). One patient had a retracted skin scarring in the gluteal area.
Conclusion: Marginal surgical resection of lipoblastomas located in the back or extremities showed a low recurrence rate at 2.8 years of follow-up and minimal complications.
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How to Cite
Manzone, P., Masquijo, J. J., Salom Taverner, M., Fiscina, S., & Innocenti, S. F. (2022). Limb and Trunk Lipoblastoma: Local Recurrence and Complications after Marginal Resection. A Multicenter Study. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 87(3), 349-359. https://doi.org/10.15417/issn.1852-7434.2022.87.3.1358
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Clinical Research
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References
1. Gilbert TJ, Goswitz JJ, Teynor JT, Griffiths HJ. Lipoblastoma of the foot. Skeletal Radiol 1996;25(3):283-6.
https:// doi.org/10.1007/s002560050081
2. Coffin CM, Lowichik A, Putnam A. Lipoblastoma (LPB): A clinicopathologic and immunohistochemical. Analysis
of 59 Cases. Am J Surg Pathol 2009;33(11):1705-12. https://doi.org/10.1097/PAS.0b013e3181b76462
3. Akhtar T, Alladi A, Ahmed SM, Siddappa OS. Giant lipoblastoma of the thigh: A rare soft tissue tumor in an infant. J Can Res Ther 2012;8:1578. https://doi.org/10.4103/0973-1482.95202
4. Jaffe RH. Recurrent lipomatous tumors of the groin: liposarcoma and lipoma pseudomyxomatodes. Arch Pathol 1926;1:381-7.
5. WHO Classification of Tumours Editorial Board. Soft Tissue and Bone Tumours. 5th ed., vol. 3. WHO Classification of Tumours Series, International Agency for Research on Cancer. Disponible en: https://publications.iarc.fr/588
6. Jung SM, Chang PY, Luo CC, Huang CS, Lai JY, Hsueh C. Lipoblastoma/lipoblastomatosis: a clinicopathologic
study of 16 cases in Taiwan. Pediatr Surg Int 2005;21(10):809-12. https://doi.org/10.1007/s00383-005-1502-x
7. Collins M, Chatten J. Lipoblastoma/lipoblastomatosis: A clinicopathologic study of 25 tumors. Am J Surg Pathol
1997;21(10):1131-7. https://doi.org/10.1097/00000478-199710000-00002
8. Kucera A, Šnajdauf J, Vyhnánek M, Morávek J, Kodet R, Stejskalová E, et al. Lipoblastoma in children: an analysis of 5 cases. Acta Chir Belg 2008;108(5):580-2. https://doi.org/10.1080/00015458.2008.11680289
9. Nam SH, Lim YJ, Kim YM. Inguinal lipoblastoma mimicking recurrent inguinal hernia. J Korean Assoc Pediatr
Surg 2014;20(2):5861. https://doi.org/10.13029/jkaps.2014.20.2.58.10
10. Armenise T, Gentile O, Orofino A, Leggio S, Lanzillotto PM, Paradies G, et al: Lipoblastoma in infant: Our experience. J Pediatr Surg Case Rep 2015;3(2):63–4. https://doi.org/10.1016/j.epsc.2014.12.001
11. Susam-Sen H, Yalcin B, Kutluk T, Tanyel FC, Haliloglu M, Akyuz C, et al. Lipoblastoma in children: Review of 12
cases. Pediatr Int 2017;59(5):545-50. https://doi.org/10.1111/ped.13239
12. Abdul-Ghafar J, Ahmad Z, Tariq MU, Kayani N, Uddin N. Lipoblastoma: a clinicopathologic review of 23 cases
from a major tertiary care center plus detailed review of literature. BMC Res Notes 2018;11(1):1-6.
https//doi.org/10.1186/s13104-018-3153-8
13. Shek KW, Cheng SS, Tse KS, Lai KC, Chan MK. Lipoblastoma: different features on magnetic resonance imaging. Hong Kong J Radiol 2015;18:302-6. https://doi.org/10.12809/hkjr1515332
14. Navarro OM. Pearls and pitfalls in the imaging of soft-tissue masses in children. Semin Ultrasound CT and MRI 2020;41(5):498-512. https://doi.org/10.1053/j.sult.2020.05.014
15. Moholkar S, Sebire NJ, Roebuck DJ. Radiological–pathological correlation in lipoblastoma and lipoblastomatosis. Pediatr Radiol 2006;36(8):851–6. https://doi.org/10.1007/s00247-006-0175-5
16. Ferreira J, Esteves G, Fonseca R, Martins C, André S, Lemos MM. Fine‐needle aspiration of lipoblastoma:
Cytological, molecular, and clinical features. Cancer Cytopathol 2017;125(12):934-9. https://doi.org/10.1002/cncy.21916
17. Agrawal P, Srinivasan R, Rajwanshi A, Gupta N, Dey P, Samujh R, et al. Fine needle aspiration cytology of
paediatric soft tissue tumours highlighting challenges in diagnosis of benign lesions and unusual malignant
tumours. Cytopathology 2019;30(3):301-8. https://doi.org/10.1111/cyt.12685
18. Kok KYY, Telisinghe PU. Lipoblastoma: clinical features, treatment, and outcome. World J Surg 2010;34(7):1517- 22. https://doi.org/10.1007/s00268-010-0466-8
19. Kerkeni Y, Sahnoun L, Ksia A, Hidouri S, Chahed J, Nouri A, et al. Lipoblastoma in childhood: About 10 cases. Afr J Paediatr Surg 2014;(11):32-4. https://doi.org/10.4103/0189-6725.129210
20. Ghosh P, Das RN, Ghosh R, Chatterjee U, Datta C, Mishra PK. Lipoblastoma and lipoblastomatosis: A
clinicopathological study of six cases. J Can Res Ther 2015;11(4):1040. https://doi.org/10.4103/0973-1482.176135
21. Morerio C, Nozza P, Tassano E, Rosanda C, Granata C, Panarello C, et al. Differential diagnosis of lipoma-like
lipoblastoma. Pediatr Blood Cancer 2009;52(1):132–4. https://doi.org/10.1002/pbc.21747
22. Krishnan J, Hathiramani V, Hastak M, Redkar RG. Myxoid lipoblastoma. Indian Pediatr 2013;50(6):603-5.
PMID: 23942405
23. Chung EB, Enzinger FM. Benign lipoblastomatosis: an analysis of 35 cases. Cancer 1973;32(2):482-92.
https://doi.org/10.1002/1097-0142(197308)32:23.0.co;2-e
24. Dao D, Najor AJ, Sun PY, Farrokhyar F, Moir CR, Ishitani MB. Follow-up outcomes of pediatric patients who
underwent surgical resection for lipoblastomas or lipoblastomatosis: a single-institution experience with a systematic review and meta-analysis. Pediatr Surg Int 2020;36(3):341-55. https://doi.org/10.1007/s00383-019-04612-z
25. Shen LY, Amin SM, Chamlin SL, Mancini AJ. Varied presentations of pediatric lipoblastoma: case series and review of the literature. Pediatr Dermatol 2017;34(2):180-6. https://doi.org/10.1111/pde.13071
https:// doi.org/10.1007/s002560050081
2. Coffin CM, Lowichik A, Putnam A. Lipoblastoma (LPB): A clinicopathologic and immunohistochemical. Analysis
of 59 Cases. Am J Surg Pathol 2009;33(11):1705-12. https://doi.org/10.1097/PAS.0b013e3181b76462
3. Akhtar T, Alladi A, Ahmed SM, Siddappa OS. Giant lipoblastoma of the thigh: A rare soft tissue tumor in an infant. J Can Res Ther 2012;8:1578. https://doi.org/10.4103/0973-1482.95202
4. Jaffe RH. Recurrent lipomatous tumors of the groin: liposarcoma and lipoma pseudomyxomatodes. Arch Pathol 1926;1:381-7.
5. WHO Classification of Tumours Editorial Board. Soft Tissue and Bone Tumours. 5th ed., vol. 3. WHO Classification of Tumours Series, International Agency for Research on Cancer. Disponible en: https://publications.iarc.fr/588
6. Jung SM, Chang PY, Luo CC, Huang CS, Lai JY, Hsueh C. Lipoblastoma/lipoblastomatosis: a clinicopathologic
study of 16 cases in Taiwan. Pediatr Surg Int 2005;21(10):809-12. https://doi.org/10.1007/s00383-005-1502-x
7. Collins M, Chatten J. Lipoblastoma/lipoblastomatosis: A clinicopathologic study of 25 tumors. Am J Surg Pathol
1997;21(10):1131-7. https://doi.org/10.1097/00000478-199710000-00002
8. Kucera A, Šnajdauf J, Vyhnánek M, Morávek J, Kodet R, Stejskalová E, et al. Lipoblastoma in children: an analysis of 5 cases. Acta Chir Belg 2008;108(5):580-2. https://doi.org/10.1080/00015458.2008.11680289
9. Nam SH, Lim YJ, Kim YM. Inguinal lipoblastoma mimicking recurrent inguinal hernia. J Korean Assoc Pediatr
Surg 2014;20(2):5861. https://doi.org/10.13029/jkaps.2014.20.2.58.10
10. Armenise T, Gentile O, Orofino A, Leggio S, Lanzillotto PM, Paradies G, et al: Lipoblastoma in infant: Our experience. J Pediatr Surg Case Rep 2015;3(2):63–4. https://doi.org/10.1016/j.epsc.2014.12.001
11. Susam-Sen H, Yalcin B, Kutluk T, Tanyel FC, Haliloglu M, Akyuz C, et al. Lipoblastoma in children: Review of 12
cases. Pediatr Int 2017;59(5):545-50. https://doi.org/10.1111/ped.13239
12. Abdul-Ghafar J, Ahmad Z, Tariq MU, Kayani N, Uddin N. Lipoblastoma: a clinicopathologic review of 23 cases
from a major tertiary care center plus detailed review of literature. BMC Res Notes 2018;11(1):1-6.
https//doi.org/10.1186/s13104-018-3153-8
13. Shek KW, Cheng SS, Tse KS, Lai KC, Chan MK. Lipoblastoma: different features on magnetic resonance imaging. Hong Kong J Radiol 2015;18:302-6. https://doi.org/10.12809/hkjr1515332
14. Navarro OM. Pearls and pitfalls in the imaging of soft-tissue masses in children. Semin Ultrasound CT and MRI 2020;41(5):498-512. https://doi.org/10.1053/j.sult.2020.05.014
15. Moholkar S, Sebire NJ, Roebuck DJ. Radiological–pathological correlation in lipoblastoma and lipoblastomatosis. Pediatr Radiol 2006;36(8):851–6. https://doi.org/10.1007/s00247-006-0175-5
16. Ferreira J, Esteves G, Fonseca R, Martins C, André S, Lemos MM. Fine‐needle aspiration of lipoblastoma:
Cytological, molecular, and clinical features. Cancer Cytopathol 2017;125(12):934-9. https://doi.org/10.1002/cncy.21916
17. Agrawal P, Srinivasan R, Rajwanshi A, Gupta N, Dey P, Samujh R, et al. Fine needle aspiration cytology of
paediatric soft tissue tumours highlighting challenges in diagnosis of benign lesions and unusual malignant
tumours. Cytopathology 2019;30(3):301-8. https://doi.org/10.1111/cyt.12685
18. Kok KYY, Telisinghe PU. Lipoblastoma: clinical features, treatment, and outcome. World J Surg 2010;34(7):1517- 22. https://doi.org/10.1007/s00268-010-0466-8
19. Kerkeni Y, Sahnoun L, Ksia A, Hidouri S, Chahed J, Nouri A, et al. Lipoblastoma in childhood: About 10 cases. Afr J Paediatr Surg 2014;(11):32-4. https://doi.org/10.4103/0189-6725.129210
20. Ghosh P, Das RN, Ghosh R, Chatterjee U, Datta C, Mishra PK. Lipoblastoma and lipoblastomatosis: A
clinicopathological study of six cases. J Can Res Ther 2015;11(4):1040. https://doi.org/10.4103/0973-1482.176135
21. Morerio C, Nozza P, Tassano E, Rosanda C, Granata C, Panarello C, et al. Differential diagnosis of lipoma-like
lipoblastoma. Pediatr Blood Cancer 2009;52(1):132–4. https://doi.org/10.1002/pbc.21747
22. Krishnan J, Hathiramani V, Hastak M, Redkar RG. Myxoid lipoblastoma. Indian Pediatr 2013;50(6):603-5.
PMID: 23942405
23. Chung EB, Enzinger FM. Benign lipoblastomatosis: an analysis of 35 cases. Cancer 1973;32(2):482-92.
https://doi.org/10.1002/1097-0142(197308)32:23.0.co;2-e
24. Dao D, Najor AJ, Sun PY, Farrokhyar F, Moir CR, Ishitani MB. Follow-up outcomes of pediatric patients who
underwent surgical resection for lipoblastomas or lipoblastomatosis: a single-institution experience with a systematic review and meta-analysis. Pediatr Surg Int 2020;36(3):341-55. https://doi.org/10.1007/s00383-019-04612-z
25. Shen LY, Amin SM, Chamlin SL, Mancini AJ. Varied presentations of pediatric lipoblastoma: case series and review of the literature. Pediatr Dermatol 2017;34(2):180-6. https://doi.org/10.1111/pde.13071