Use of Structural Allograft and Post-Surgical Infections

Keywords: Structural allograft, bone bank, infection, complications

Abstract

The use of allografts carries the risk of various complications. Among the most frequent is infection. An important risk factor for infection with the use of bone grafts is the transmission of germs through the graft itself. Our objectives are to determine if there is a relationship between possible contamination of the grafts from this bank and postoperative infections; demonstrate how the proper donor selection, procurement, and processing of the graft decrease the rate of contamination; and report other complications relatedto the quality of the graft. Materials and Methods: We selected patients who received structural bone grafts from our bank.All grafts were microbiologically studied. A review of the health records, anamnesis, physical examination, and radiographs was performed to evaluate infection and other complications. The ISOLS Osseointegration Scale was used to asses the consolidation of the grafts. Results: No graft contamination was detected. One case (7.7%) of infection by carbapenemase-producing Klebsiella pneumoniae (KPC) and 3 cases (23%) of nonunion were identified. Consolidation was good to excellent in 77% of cases, satisfactory in 8%, and poor in 15%. No other complications were found. Conclusion: There is a risk for infection transmission with structural allograft. Regulated donor selection criteria and control of bone bank procedures reduce the risk of infection due to graft contamination and other complications related to graft quality.

Downloads

Download data is not yet available.

Author Biographies

Fernando Daniel Jorge, Orthopedics and Traumatology Service, Hospital Alemán, Autonomous City of Buenos Aires, Argentina
Orthopedics and Traumatology Service, Hospital Alemán, Autonomous City of Buenos Aires, Argentina
José María Varaona, Orthopedics and Traumatology Service, Hospital Alemán, Autonomous City of Buenos Aires, Argentina
Orthopedics and Traumatology Service, Hospital Alemán, Autonomous City of Buenos Aires, Argentina
Mariela Basso, Orthopedics and Traumatology Service, Hospital Alemán, Autonomous City of Buenos Aires, Argentina
Orthopedics and Traumatology Service, Hospital Alemán, Autonomous City of Buenos Aires, Argentina

References

Sims L, Kulyk P, Woo A. Intraoperative culture positive allograft bone and subsequent postoperative infections: a retrospective review. Can J Surg 2017;60(2):94-100. https://doi.org/10.1503/cjs.008016

Zamborsky R, Svec A, Bohac M, Kilian M, Kokavec M. Infection in bone allograft transplants. Exp Clin Transplant

;14(5):484-90. PMID: 27733106

Rogers BA, Sternheim A, De Iorio M, Backstein D, Safir O, Gross AE. Proximal femoral allograft in revision hip

surgery with severe femoral bone loss: a systematic review and metaanalysis. J Arthroplasty 2012;27(6): 829-36.

https://doi.org/10.1016/j.arth.2011.10.014

Aponte-Tinao LA, Ritacco LE, Albergo JI, Ayerza MA, Muscolo DL, Farfalli GL. The principles and applications

of fresh frozen allografts to bone and joint reconstruction. Orthop Clin North Am 2014;45(2):257-69.

https://doi.org/10.1016/j.ocl.2013.12.008

Lemos Azi M, Aprato A, Santi I, Kfuri M Jr, Masse A, Joeris A. Autologous bone graft in the treatment of posttraumatic bone defects: a systematic review and meta-analysis. BMC Musculoskelet Disord 2016;17(1):465.

https://doi.org/10.1186/s12891-016-1312-4

Mikhael MM, Huddleston PM, Nassr A. Postoperative culture positive surgical site infections after the use of

irradiated allograft, nonirradiated allograft, or autograft for spinal fusion. Spine 2009;34(22):2466-8.

https://doi.org/10.1097/BRS.0b013e3181b1fef5

Varaona JM. Banco de Tejido Óseo: Pautas para un funcionamiento eficiente y seguro. Tesis de Doctorado en

Medicina. Universidad de Buenos Aires, Facultad de Medicina, 2006.

Chapman PG, Villar RN. The bacteriology of bone allografts. J Bone Joint Surg 1992;74(3):398-9.

https://doi.org/10.1302/0301-620X.74B3.1587886

Escribano Rey RJ, Vázquez García BL. Contamination of tissue allografts from a deceased donor through haematic dissemination: a case study. Cell Tissue Bank 2010;11(3):295-8. https://doi.org/10.1007/s10561-009-9153-0

Veen MR, Bloem RM, Petit PLC. Sensitivity and negative predictive value of swap cultures in musculoskeletal

allograft procurement. Clin Orthop Relat Res 1994;300:259-63. PMID: 8131346

Barrios RH Leyes M, Amillo S, Oteiza C. Bacterial contamination of allografts. Acta Orthop Belg 1994;60(2):152-

PMID: 8053313

James LA, Ibrahim T, Esler CN. Microbiological culture results for the femoral head. Are they important to the

donor? J Bone Joint Surg Br 2004;86(6):797-800. https://doi.org/10.1302/0301-620x.86b6.14783

Tomford WW. Transmission of disease through transplantation of musculoskeletal allografts. J Bone Joint Surg Am 1995;77(11):1742-4. https://doi.org/10.2106/00004623-199511000-00017

Schratt HE, Regel G, Kiesewetter B, Tscherne H. [HIV infection caused by cold preserved bone transplants].

Unfallchirurg 1996;99(9):679-84. [En alemán] https://doi.org/10.1007/s001130050042

Aponte-Tinao LA, Ayerza MA, Muscolo DL, Farfalli GL. What are the risk factors and management options for

infection after reconstruction with massive bone allografts? Clin Orthop Relat Res 2016;474(3):669-73.

https://doi.org/10.1007/s11999-015-4353-3

Mankin HJ, Hornicek FJ, Raskin KA. Infection in massive bone allografts. Clin Orthop Relat Res 2005;(432):210-6. https://doi.org/10.1097/01.blo.0000150371.77314.52

Dion N, Sim FH. The use of allografts in orthopaedic surgery. Part I: the use of allografts in musculoskeletal

oncology. J Bone Joint Surg Am 2002;84:644-54. Disponible en:

https://www.proquest.com/openview/f0b36838f75fd8144404891634c121d7/1?pq-origsite=gscholar&cbl=289

Enneking WF, Mindel ER. Observations on massive retrieved human allografts. J Bone Joint Surg Am 1991;73(8): 123-34. PMID: 1890115

Frisoni T, Cevolani L, Giorgini A, Dozza B, Donati DM. Factors affecting outcome of massive intercalary bone

allografts in the treatment of tumours of the femur. J Bone Joint Surg Br 2012;94(6):836-41. https://doi.org/10.1302/0301-620X.94B6.28680

Delloye C, van Cauter M, Dufrane D, Francq BG, Docquier PL, Cornu O. Local complications of massive bone

allografts: an appraisal of their prevalence in 128 patients. Acta Orthop Belg 2014;80(2):196-204. PMID: 25090792

Aponte-Tinao L, Farfalli G, Ritacco L, Ayersa M, Muscolo L. Intercalary femur allografts are an acceptable

alternative after tumor resection. Clin Orthop Rel Res 2012;470(3):728-34. https://doi.org/10.1007/s11999-011-1952-5

Enneking WF, Campanacci DA. Retrieved human allografts: a clinicopathological study. J Bone Joint Surg Am

;83(7):971-86. PMID: 11451965

Hazan EJ, Hornicek FJ, Tomford WW. The effect of adjuvant chemotherapy on osteoarticular allografts. Clin Orthop 2001;(385):176-81. https://doi.org/10.1097/00003086-200104000-00027

Davy DT. Biomechanical issues in bone transplantation. Clin Orthop North Am 1999;30(4):553-63.

https://doi.org/10.1016/s0030-5898(05)70108-5

Published
2022-02-14
How to Cite
Jorge, F. D., Varaona, J. M., & Basso, M. (2022). Use of Structural Allograft and Post-Surgical Infections. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 87(1), 23-33. https://doi.org/10.15417/issn.1852-7434.2022.87.1.1138
Section
Clinical Research

Most read articles by the same author(s)