Protocolo multimodal farmacológico perioperatorio para la cirugía de columna en pediatría

Palabras clave: Cirugía de columna, pediatría, dolor posoperatorio, analgesia multimodal

Resumen

Introducción: La cirugía de columna es uno de los procedimientos con mayor morbimortalidad dentro de la población pediátrica; el manejo farmacológico del dolor en dicha población aún no se encuentra estandarizado. La analgesia multimodal trata de responder a esta problemática. Objetivo: Sobre la base de una revisión sistemática de la bibliografía, desarrollar un detallado protocolomultimodal farmacológico para el manejo del dolor pre- y posoperatorio intra/extrahospitalario para la cirugía de columna en niños. Materiales y Métodos: Se realizó una revisión sistemática de textos completos en inglés o español en PubMed, Embase, Cochrane Library y LILACS Database publicados entre 2000 y 2021; se aplicó el diagrama de flujo PRISMA. Resultados: De 756 artículos preseleccionados, 38 fueron incluidos en la evaluación final. Dada la dificultad bioética de desarrollar trabajos en formato de ensayos clínicos con fármacos y combinaciones de ellos en la población pediátrica, desarrollamos un protocolo detallado de manejo del dolor pre- y posoperatorio por vía intravenosa/oral, intra- y extrahospitalario, para aplicar en niños sometidos a cirugía de columna. Conclusión: Logramos desarrollar un detallado protocolo multimodal farmacológico para el perioperatorio intra- y extrahospitalario de cirugía de columna en niños, sencillo y reproducible, tendiente a acelerar la recuperación funcional del paciente y disminuir los costos socioeconómicos globales.Nivel de Evidencia: II

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Biografía del autor/a

Lucas Piantoni, Servicio de Patología Espinal, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina
Servicio de Patología Espinal, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina
Carlos A. Tello, Servicio de Patología Espinal, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina
Servicio de Patología Espinal, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina
Rodrigo G. Remondino, Servicio de Patología Espinal, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina
Servicio de Patología Espinal, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina
Eduardo Galaretto, Servicio de Patología Espinal, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina
Servicio de Patología Espinal, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina
Mariano A. Noel, Servicio de Patología Espinal, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina
Servicio de Patología Espinal, Hospital de Pediatría “Prof. Dr. Juan P. Garrahan”, Ciudad Autónoma de Buenos Aires, Argentina

Citas

Milbrandt TA, Singhal M, Minter C, McClung A, Talwalkar VR, Iwinski HJ, et al. A comparison of three methods of pain control for posterior spinal fusions in adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 2009;34(14):1499-503. https://doi.org/10.1097/BRS.0b013e3181a90ceb

Walker CT, Gullotti DM, Prendergast V, Radosevich J, Grimm D, Cole TS, et al. Implementation of standardized

multimodal postoperative analgesia protocol improves pain control, reduces opioid consumption, and shortens

length of hospital stay after posterior lumbar spinal fusion. Neurosurgery 2020;87(1):130-6. https://doi.org/10.1093/neuros/nyz312

Cozowicz C, Bekeris J, Poeran J, Zubizarreta N, Schwenk E, Girardi F, et al. Multimodal pain management and

postoperative outcomes in lumbar spine fusion surgery: A population-based cohort study. Spine (Phila Pa 1976)

;45(9):580-9. https://doi.org/10.1097/BRS.0000000000003320

Piantoni L, Tello CA, Francheri Wilson IA, Remondino R, Galaretto E, et al. Manejo del dolor posoperatorio

por cirugía de columna en la población pediátrica. Resultados preliminares. Rev Asoc Argent Ortop Traumatol

;84(3):224-35. https//doi.org/10.15417/issn.1852-7434.2019.84.3.9314

Yousefifard M, Askarian-Amiri S, Madani Neishaboori A, Sadeghi M, Saberian P, Baratloo A. Pre-hospital pain

management; a systematic review of proposed guidelines. Arch Acad Emerg Med 2019;7(1):e55. PMID: 31875209

Oliveira CB, Maher CG, Pinto RZ, Traeger AC, Lin CWC, Chenot JF, et al. Clinical practice guidelines for the

management of non-specific low back pain in primary care: an updated overview. Eur Spine J 2018;27(11):2791-

https://doi.org/10.1007/s00586-018-5673-2

Hsu JR, Mir H, Wally MK, Seymour RB. Orthopaedic Trauma Association Musculoskeletal Pain Task Force. Clinical practice guidelines for pain management in acute musculoskeletal injury. J Orthop Trauma 2019;33(5):e158-e182. https://doi.org/10.1097/BOT.0000000000001430

Aubrun F, Nouette-Gaulain K, Fletcher D, Belbachir A, Beloeil H, Carles M, et al. Revision of expert panel’s

guidelines on postoperative pain management. Anaesth Crit Care Pain Med 2019;38(4):405-11. https://doi.org/10.1016/j.accpm.2019.02.011

Shah SA, Guidry R, Kumar A, White T, King A, Heffernan MJ. Current trends in pediatric spine deformity surgery: multimodal pain management and rapid recovery. Global Spine J 2020;10(3):346-52. https://doi.org/10.1177/2192568219858308

Sheffer BW, Kelly DM, Rhodes LN, Sawyer JR. Perioperative pain management in pediatric spine surgery. Orthop Clin North Am 2017;48(4):481-6. https://doi.org/10.1016/j.ocl.2017.06.004

Johnson MA, Andras LM, Andras LE, Ellington MD, Upasani VV, Shah AS. What’s new in pain management for

pediatric orthopaedic surgery. J Pediatr Orthop 2021;41(10):e923-3928. https://doi.org/10.1097/BPO.0000000000001956

Borgeat A, Blumenthal S. Postoperative pain management following scoliosis surgery. Curr Opin Anaesthesiol

;21(3):313-6. https://doi.org/10.1097/ACO.0b013e3282f82baa

Practice Guidelines for Acute Pain Management in the Perioperative Setting: An Updated Report by the American Society of Anesthesiologists Task Force on Acute Pain Management. Anesthesiology 2012;116:248–273.

https://doi.org/10.1097/ALN.0b013e31823c1030

Aoki Y, Iwata H, Akinaga C, Shiko Y, Kawasaki Y, Kobayashi K, et al. Intraoperative remifentanil dosage in surgery for adolescent idiopathic scoliosis does not increase postoperative opioid consumption when combined with epidural analgesia: A retrospective cohort study. Cureus 2021;13(8):e17361. https://doi.org/10.7759/cureus.17361

Bean BA, Connor PM, Schiffern SC, Hamid N. Outpatient shoulder arthroplasty at an ambulatory surgery center using a multimodal pain management approach J Am Acad Orthop Surg Glob Res Rev 2018;2:e064.

https://doi.org/10.5435/JAAOSGlobal-D-18-00064

Creary SE, Chisolm DJ, Wrona SK, Cooper JN. Opioid prescription filling trends among children with sickle cell

disease after the release of state-issued guidelines on pain management. Pain Med 2020;21(10):2583-92.

https://doi.org/10.1093/pm/pnaa002

Joshi GP, Kehlet H. Postoperative pain management in the era of ERAS: An overview. Best Pract Res Clin

Anaesthesiol 2019;33(3):259-67. https://doi.org/10.1016/j.bpa.2019.07.016

Joshi GP, Kehlet H; PROSPECT Working Group. Guidelines for perioperative pain management: need for reevaluation. Br J Anaesth 2017;119(4):703-6. https://doi.org/10.1093/bja/aex304

Jones JS, Cotugno RE, Singhal NR, Soares N, Semenova J, Nebar S, et al. Evaluation of dexmedetomidine and

postoperative pain management in patients with adolescent idiopathic scoliosis: conclusions based on a retrospective study at a tertiary pediatric hospital. Pediatr Crit Care Med 2014;15(6):e247-52.

https://doi.org/10.1097/PCC.0000000000000119

Rawal N. Current issues in postoperative pain management. Eur J Anaesthesiol 2016;33(3):160-71.

https://doi.org/10.1097/EJA.0000000000000366

Zieliński J, Morawska-Kochman M, Zatoński T. Pain assessment and management in children in the postoperative period: A review of the most commonly used postoperative pain assessment tools, new diagnostic methods and the latest guidelines for postoperative pain therapy in children. Adv Clin Exp Med 2020;29(3):365-74. https://doi.org/10.17219/acem/112600

McNicol ED, Rowe E, Cooper TE. Ketorolac for postoperative pain in children. Cochrane Database Syst Rev

;7(7):CD012294. https://doi.org/10.1002/14651858.CD012294.pub2

Yoo JS, Ahn J, Buvanendran A, Singh K. Multimodal analgesia in pain management after spine surgery. J Spine

Surg 2019;5(2):S154-9. https://doi.org/10.21037/jss.2019.05.04

Rajpal S, Gordon DB, Pellino TA, Strayer AL, Brost D, Trost GR, et al. Comparison of perioperative oral

multimodal analgesia versus IV PCA for spine surgery. J Spinal Disord Tech 2010;23(2):139-45.

https://doi.org/10.1097/BSD.0b013e3181cf07ee

Rao KE, Krodel D, Toaz EE, Fanelli J, Hajduk J, Kato K, et al. Introduction of an enhanced recovery pathway

results in decreased length of stay in patients with adolescent idiopathic scoliosis undergoing posterior spinal fusion: A description of implementation strategies and retrospective before-and-after study of outcomes. J Clin Anesth 2021;75:110493. https://doi.org/10.1016/j.jclinane.2021.110493

YaDeau JT, Dines DM, Liu SS, Gordon MA, Goytizolo EA, Lin Y, et al. What pain levels do TSA patients

experience when given a long-acting nerve block and multimodal analgesia? Clin Orthop Relat Res 2019;477:622-

https://doi.org/10.1097/CORR.0000000000000597

Pagnotto MR, Pagnano MW. Multimodal pain management with peripheral nerve blocks for total knee arthroplasty. Instr Course Lect 2012;61:389-95. PMID: 22301247

Li WT, Bell KL, Yayac M, Barmann JA, Star AM, Austin MS. A postdischarge multimodal pain management

cocktail following total knee arthroplasty reduces opioid consumption in the 30-day postoperative period: A grouprandomized trial. J Arthroplasty 2021;(36) 164e172. https://doi.org/10.1016/j.arth.2020.07.060

Karam JA, Schwenk ES, Parvizi J. An update on multimodal pain management after total joint arthroplasty. J Bone Joint Surg Am 2021;103:1652-62. https://doi.org/10.2106/JBJS.19.01423

Anderson DE, Duletzke NT, Pedigo EB, Halsey MF. Multimodal pain control in adolescent posterior spinal fusion patients: a double-blind, randomized controlled trial to validate the effect of gabapentin on postoperative pain control, opioid use, and patient satisfaction. Spine Deform 2020;8(2):177-85. https://doi.org/ 10.1007/s43390-020-00038-z

Muhly WT, Beltran RJ, Bielsky A, Bryskin RB, Chinn C, Choudhry DK, et al. Perioperative management and

in-hospital outcomes after minimally invasive repair of pectus excavatum: a multicenter registry report from the

society for pediatric anesthesia improvement network. Anesth Analg 2019;128(2):315-27. https://doi.org/10.1213/ANE.0000000000003829

Lee CS, Merchant S, Chidambaran V. Postoperative pain management in pediatric spinal fusion surgery for

idiopathic scoliosis. Paediatr Drugs 2020;22(6):575-601. https://doi.org/10.1007/s40272-020-00423-1

Chou R, Côté P, Randhawa, Torres P, Yu H, Nordin M, et al. The Global Spine Care Initiative: applying evidencebased guidelines on the non-invasive management of back and neck pain to low- and middle-income communities. Eur Spine J 2018;27(6):851-60. https://doi.org/10.1007/s00586-017-5433-8

Parrish JM, Jenkins NW, Brundage TS, Hrynewycz NM, Podnar J, Buvanendran A, et al. Outpatient minimally

invasive lumbar fusion using multimodal analgesic management in the ambulatory surgery setting. Int J Spine Surg 2020;14(6):970-81. https://doi.org/10.14444/7146

Hong RA, Gibbons KM, Li GY, Holman A, Voepel-Lewis T. A retrospective comparison of intrathecal morphine

and epidural hydromorphone for analgesia following posterior spinal fusion in adolescents with idiopathic scoliosis. Paediatr Anaesth 2017;27(1):91-7. https://doi.org/ 10.1111/pan.13037

Koes BW, van Tulder M, Lin CW, Macedo LC, McAuley J, Maher C. An updated overview of clinical guidelines

for the management of non-specific low back pain in primary care. Eur Spine J 2010;19(12):2075-94. https://doi.org/10.1007/s00586-010-1502-y

Man JY, Gurnaney HG, Dubow SR, DiMaggio TJ, Kroeplin GR, Adzick S, et al. A retrospective comparison of

thoracic epidural infusion and multimodal analgesia protocol for pain management following the minimally invasive repair of pectus excavatum. Paediatr Anaesth 2017;27(12):1227-34. https://doi.org/10.1111/pan.13264

Devin CJ, McGirt MJ. Best evidence in multimodal pain management in spine surgery and means of assessing

postoperative pain and functional outcomes. J Clin Neurosci 2015;22(6):930-8. https://doi.org/10.1016/j.jocn.2015.01.003

Frizzell KH, Cavanaugh PK, Herman MJ. Pediatric perioperative pain management. Orthop Clin North Am

;48(4):467-80. https://doi.org/10.1016/j.ocl.2017.06.007

Wong JJ, Côté P, Sutton DA, Randhawa K, Yu H, Varatharajan S, et al. Clinical practice guidelines for the

noninvasive management of low back pain: A systematic review by the Ontario Protocol for Traffic Injury

Management (OPTIMa) Collaboration. Eur J Pain 2017;21(2):201-16. https://doi.org/ 10.1002/ejp.931

Young VB. Effective management of pain and anxiety for the pediatric patient in the emergency department. Crit Care Nurs Clin North Am 2017;29(2):205-16. https://doi.org/10.1016/j.cnc.2017.01.007

Bull J, Grogan S. Children having spinal surgery to correct scoliosis: A qualitative study of parents’ experiences. J Health Psychol 2010;15(2):299-309. https://doi.org/10.1177/1359105309351607

Ntalouka MP, Brotis AG, Bareka MV, Stertsou ES, Fountas KN, Arnaoutoglou EM. Multimodal analgesia in spine surgery: An umbrella review. World Neurosurg 2021;149:129-39. https://doi.org/10.1016/j.wneu.2021.02.040

Mathiesen O, Dahl B, Thomsen BA, Kitter B, Sonne N, Dahl JB, et al. A comprehensive multimodal pain treatment reduces opioid consumption after multilevel spine surgery. Eur Spine J 2013;22(9):2089-96.

https://doi.org/10.1007/s00586-013-2826-1

Momon A, Verdier B, Dolomie JO, Gardette M, Pereira B, Curt I, et al. A Single preoperative administration

of dexamethasone, low-dose pregabalin, or a combination of the 2, in spinal surgery, does not provide a better

analgesia than a multimodal analgesic protocol alone. Clin J Pain 2019;35(7):594-601. https://doi.org/10.1097/AJP.0000000000000719

Kaye AD, Chernobylsky DJ, Thakur P, Siddaiah H, Kaye RJ, Eng LK, et al. Dexmedetomidine in Enhanced

Recovery After Surgery (ERAS) Protocols for postoperative pain. Curr Pain Headache Rep 2020;24(5):21.

https://doi.org/10.1007/s11916-020-00853-z

Song K, Melroy MJ, Whipple OC. Optimizing multimodal analgesia with intravenous acetaminophen and opioids in postoperative bariatric patients. Pharmacotherapy 2014;34(Suppl 1):14-21S. https://doi.org/10.1002/phar.1517

Chan P, Skaggs DL, Sanders AE, Villamor GA, Choi PD, Tolo VT, et al. Pain is the greatest preoperative concern

for patients and parents before posterior spinal fusion for adolescent idiopathic scoliosis. Spine (Phila Pa 1976)

;42(21):E1245-50. https://doi.org/10.1097/BRS.0000000000002147

Landman Z, Oswald T, Sanders J, Diab M. Spinal Deformity Study Group. Prevalence and predictors of pain in

surgical treatment of adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 2011;36(10):825-9.

https://doi.org/10.1097/BRS.0b013e3181de8c2b

Wong GT, Yuen VM, Chow BF, Irwin MG. Persistent pain in patients following scoliosis surgery. Eur Spine J

;16(10):1551-6. https://doi.org/10.1007/s00586-007-0361-7

Pestieau SR, Finkel JC, Junqueira MM, Cheng Y, Lovejoy JF, Wang J, et al. Prolonged perioperative infusion of

low-dose ketamine does not alter opioid use after pediatric scoliosis surgery. Paediatr Anaesth 2014;24(6):582-90. https://doi.org/10.1111/pan.12417

Hwang SW, Pendleton C, Samdani AF, Bastrom TP, Keeny H, Lonner BS, et al. Preoperative SRS pain score

is the primary predictor of postoperative pain after surgery for adolescent idiopathic scoliosis: an observational

retrospective study of pain outcomes from a registry of 1744 patients with a mean follow-up of 3.4 years. Eur Spine J 2020;29, 754–760. https://doi.org/10.1007/s00586-020-06293-y

Vademecum Intranet. Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan. Sitio web. 2021. Disponible en: https://farmacia.garrahan.gov.ar/Vademecum/Busqueda

Publicado
2022-12-31
Cómo citar
Piantoni, L., Tello, C. A., Remondino, R. G., Galaretto, E., & Noel, M. A. (2022). Protocolo multimodal farmacológico perioperatorio para la cirugía de columna en pediatría. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 87(6), 825-837. https://doi.org/10.15417/issn.1852-7434.2022.87.6.1490
Sección
Revisión Sistemática

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