Subscapularis Fibromatosis as a Cause of Winged Scapula. Case Report and Literature Review

Keywords: Winged scapula, desmoid tumor, treatment

Abstract

Winged scapula is usually caused by neurological injuries to both the spinal nerve and the long thoracic nerve. Its presence as a result of a ventral scapular tumor makes initial diagnosis difficult. We present the case of a young woman with limited external shoulder rotation, no known traumatic history, and images consistent with a soft tissue lesion dependent on subscapular muscle aponeurosis, which was confirmed by biopsy as a desmoid tumor. Although it is a benign, self-limiting tumor, it has an alarmingly high rate of relapse after resection, so many treatments are available, and many teams choose to closely monitor the patient’s prognostic factors and functional limitations, obtaining satisfactory outcomes and, in some series, superior to those of surgical treatment.

Downloads

Download data is not yet available.

Author Biographies

Miguel González López, Orthopedic Surgery and Traumatology Service, Hospital Universitario de Getafe, Madrid, Spain
Orthopedic Surgery and Traumatology Service, Hospital Universitario de Getafe, Madrid, Spain
Renato Alessandro Delfino Carrillo, Orthopedic Surgery and Traumatology Service, Hospital Universitario de Getafe, Madrid, Spain
Orthopedic Surgery and Traumatology Service, Hospital Universitario de Getafe, Madrid, Spain
Pablo César Arviza-Lorenzo, Orthopedic Surgery and Traumatology Service, Hospital Universitario de Getafe, Madrid, Spain
Orthopedic Surgery and Traumatology Service, Hospital Universitario de Getafe, Madrid, Spain
Cristina Madrid de la Serna, Orthopedic Surgery and Traumatology Service, Hospital Universitario de Getafe, Madrid, Spain
Orthopedic Surgery and Traumatology Service, Hospital Universitario de Getafe, Madrid, Spain
Lydia Cecilia Escribano Rueda, Orthopedic Surgery and Traumatology Service, Hospital Universitario de Getafe, Madrid, Spain
Orthopedic Surgery and Traumatology Service, Hospital Universitario de Getafe, Madrid, Spain

References

Eastley N, McCulloch T, Esler C, Hennig I, Fairbairn J, Gronchi A, et al. Extra-abdominal desmoid fibromatosis: A

review of management, current guidance and unanswered questions. Eur J Surg Oncol 2016;42(7):1071-83.

https://doi.org/10.1016/j.ejso.2016.02.012

Giarola M, Wells D, Mondini P, Pilotti S, Sala P, Azzarelli A, et al. Mutations of adenomatous polyposis coli (APC)

gene are uncommon in sporadic desmoid tumours. Br J Cancer 1998;78(5):582-7. https://doi.org/10.1038/bjc.1998.544

Nieuwenhuis MH, Casparie M, Mathus-Vliegen LM, Dekkers OM, Hogendoorn PC, Vasen HF. A nation-wide

study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses. Int J Cancer

;129(1):256-61. https://doi.org/10.1002/ijc.25664

Singh Sikka R, Vora M. Desmoid tumor of the subscapularis presenting as isolated loss of external rotation of the shoulder. J Bone Joint Surg Am 2004;86(1):159-64. https://doi.org/10.2106/00004623-200401000-00026

Rock M, Pritchard D. Extra-abdominal desmoid tumors. J Bone Joint Surg Am 1984;66(9):1369-74. PMID: 6501332

Pignatti G, Barbanti-Bròdano G, Ferrari D, Gherlinzoni F, Bertoni F, Bacchini P, et al. Extraabdominal desmoid

tumor. Clin Orthop Relat Res 2000;375(375):207-13. PMID: 10853171

Mankin HJ, Hornicek FJ, Springfield DS. Extra-abdominal desmoid tumors: a report of 234 cases. J Surg Oncol

;102(5):380-4. https://doi.org/10.1002/jso.21433

Nuyttens JJ, Rust PF, Thomas CR Jr, Turrisi AT 3rd. Surgery versus radiation therapy for patients with aggressive

fibromatosis or desmoid tumors: A comparative review of 22 articles. Cancer 2000;88(7):1517-23. PMID: 10738207

Fontanesi J, Mott MP, Kraut MJ, Lucas DP, Miller PR. The role of postoperative irradiation in the treatment of

locally recurrent incompletely resected extra-abdominal desmoid tumors. Sarcoma 2004;8(2-3):83-6.

https://doi.org/10.1080/13577140410001710512

Nishida Y, Tsukushi S, Shido Y, Wasa J, Ishiguro N, Yamada Y. Successful treatment with meloxicam, a

cyclooxygenase-2 inhibitor, of patients with extra-abdominal desmoid tumors: a pilot study. J Clin Oncol 2010;28(6):e107-9. https://doi.org/10.1200/JCO.2009.25.5950

Mullen JT, DeLaney TF, Rosenberg AE, Le L, Iafrate AJ, Kobayashi W, et al. β-Catenin mutation status and

outcomes in sporadic desmoid tumors. Oncologist 2013;18(9):1043-9. https://doi.org/10.1634/theoncologist.2012-0449

Kasper B, Baumgarten C, Bonvalot S, Haas R, Haller F, Hohenberger P, et al. Desmoid Working Group.

Management of sporadic desmoid-type fibromatosis: a European consensus approach based on patients’ and

professionals’ expertise - a sarcoma patients EuroNet and European Organisation for Research and Treatment of

Cancer/Soft Tissue and Bone Sarcoma Group initiative. Eur J Cancer 2015;51(2):127-36. https://doi.org/10.1016/j.ejca.2014.11.005

Constantinidou A, Jones RL, Scurr M, Al-Muderis O, Judson I. Advanced aggressive fibromatosis: Effective

palliation with chemotherapy. Acta Oncol 2011;50(3):455-61. https://doi.org/10.3109/0284186X.2010.509105

Gennatas S, Chamberlain F, Smrke A, Stewart J, Hayes A, Roden L, et al. A Timely oral option: Single-agent

vinorelbine in desmoid tumors. Oncologist 2020;25(12):e2013-e2016. https://doi.org/10.1002/ONCO.13516

Gounder MM, Lefkowitz RA, Keohan ML, D’Adamo DR, Hameed M, Antonescu CR, et al. Activity of sorafenib

against desmoid tumor/deep fibromatosis. Clin Cancer Res 2011;17(12):4082-90. https://doi.org/10.1158/1078-0432.CCR-10-3322

Gounder MM, Mahoney MR, Van Tine BA, Ravi V, Attia S, Deshpande HA, et al. Sorafenib for advanced and

refractory desmoid tumors. N Engl J Med 2018;379(25):2417-28. https://doi.org/10.1056/NEJMoa1805052

Kasper B. Systemic treatment approaches for sporadic desmoid-type fibromatosis: scarce evidence and recommendations. Oncol Res Treat 2015;38(5):244-8. https://doi.org/10.1159/000381909

Janinis J, Patriki M, Vini L, Aravantinos G, Whelan JS. The pharmacological treatment of aggressive fibromatosis: a systematic review. Ann Oncol 2003;14(2):181-90. https://doi.org/10.1093/annonc/mdg064

Fiore M, Rimareix F, Mariani L, Domont J, Collini P, Le Péchoux C, et al. Desmoid-type fibromatosis: a front-line

conservative approach to select patients for surgical treatment. Ann Surg Oncol 2009;16(9):2587-93. https://doi.org/10.1245/s10434-009-0586-2

Waddell WR, Kirsch WM. Testolactone, sulindac, warfarin, and vitamin K1 for unresectable desmoid tumors. Am J Surg 1991;161(4):416-21. https://doi.org/10.1016/0002-9610(91)91102-o

Ruspi L, Cananzi FCM, Sicoli F, Samà L, Renne SL, Marrari A, et al. Event-free survival in desmoid-type fibromatosis (DTF): A pre-post comparison of upfront surgery versus wait-and-see approach. Eur J Surg Oncol

;47(5):1196-1200. https://doiorg/10.1016/j.ejso.2020.08.009

Penel N, Le Cesne A, Bui BN, Perol D, Brain EG, Ray-Coquard I, et al. Imatinib for progressive and recurrent

aggressive fibromatosis (desmoid tumors): an FNCLCC/French Sarcoma Group phase II trial with a long-term

follow-up. Ann Oncol 2011;22(2):452-7. https://doi.org/10.1093/annonc/mdq341

Amary MF, Pauwels P, Meulemans E, Roemen GM, Islam L, Idowu B, et al. Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool. Am J Surg Pathol 2007;31(9):1299-309. https://doi.org/10.1097/PAS.0b013e31802f581a

Published
2023-08-17
How to Cite
González López, M., Delfino Carrillo, R. A., Arviza-Lorenzo, P. C., Madrid de la Serna, C., & Escribano Rueda, L. C. (2023). Subscapularis Fibromatosis as a Cause of Winged Scapula. Case Report and Literature Review. Revista De La Asociación Argentina De Ortopedia Y Traumatología, 88(4), 444-450. https://doi.org/10.15417/issn.1852-7434.2023.88.4.1674
Section
Case Presentations